木质素季铵盐-海藻酸钠聚合物负载阿维菌素粉体的制备及抗紫外光性能分析

doi:10.3969/j.issn.1673-5854.2015.03.004

生物质化学工程 ›› 2015, Vol. 49 ›› Issue (3): 17-22.doi: 10.3969/j.issn.1673-5854.2015.03.004

木质素季铵盐-海藻酸钠聚合物负载阿维菌素粉体的制备及抗紫外光性能分析

卢晶¹, 罗华超¹, 张琼², 方桂珍¹, 任世学¹

1. 东北林业大学材料科学与工程学院, 黑龙江哈尔滨 150040;
2. 中国林业科学研究院林产化学工业研究所, 江苏南京 210042

收稿日期:2015-01-08 出版日期:2015-05-30 发布日期:2015-08-04
通讯作者: 方桂珍,教授,博士生导师,主要从事木质素与纤维素等天然高分子化学领域研究;E-mail:Fanggz_0@163.com。 E-mail:Fanggz_0@163.com
作者简介:卢晶(1991—),女,吉林白山人,硕士生,主要从事木质素化学研究
基金资助:
"十二五"农村领域国家科技计划课题项目(2012BAD24B0403);国家自然科学基金资助项目(31170542)

Preparation and UV-shielding Properties of Quaternary Ammonium Salt of Lignin-sodium Alginate Polymer Loading Avermectin

LU Jing¹, LUO Hua-chao¹, ZHANG Qiong², FANG Gui-zhen¹, REN Shi-xue¹

1. College of Material Science and Technology, Northeast Forestry University, Harbin 150040, China;
2. Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, China

Received:2015-01-08 Online:2015-05-30 Published:2015-08-04

摘要/Abstract

摘要： 以三甲基木质素季铵盐-海藻酸钠(QL-SA)为载体,用物理混合法制备了阿维菌素缓释聚合物(AVM-QL-SA),利用FT-IR对其结构进行了表征,探讨了交联剂用量、药物加入量、体系pH值等因素对载药量和包封率的影响,并对其缓释性能和抗紫外光降解进行了研究。结果表明:阿维菌素(AVM)均匀的混合在QL-SA载体中,主要以物理混合为主;最佳制备条件为:戊二醛为5%(以单体质量分数计)、药物加入量为1%(以单体质量分数计)、体系pH值为8.5,载药量和包封率分别达到1.36%和73.36%;阿维菌素缓释聚合物粒径符合正态分布,平均粒径为83.90 μm;阿维菌素缓释聚合物具有很好的缓释性能,在乙醇/水(体积比1:1)中释放30 h,累计释放率为88.97%;经8 h紫外光照射,阿维菌素原药中AVM残留量为6.24%,阿维菌素缓释聚合物中AVM残留量为37.75%,具有良好的抗紫外分解性能。

关键词: 木质素季铵盐, 聚合物, 阿维菌素, 缓释

Abstract: Slow-release polymer of avermectin (AVM-QL-SA) was prepared using trimethyl quaternary ammonium salt of lignin-sodium alginate (QL-SA) as carriers by physical blending.Based on the structure elucidation of slow release-polymer through FT-IR, the effects of the factors such as the dosage of crosslink agent and abamectin as well as the pH fluctuation on the drug loading (DL) and the encapsulation efficieney (EE) were discussed.The results indicated that the avermectin was mixed with QL-SA uniformly and no chemical reaction happened.The optimal process conditions of AVM-QL-SA were the dosage of glutaraldehyde 4%(solids content), drug loading of 1%, the pH of reaction system 8.5(washing the product with water to neutral).Under these conditions, the obtained DL and EE were 1.36% and 73.36%, respectively and the particle size of AVM-QL-SA accorded with normal distribution with average particle size of 83.90 μm.AVM-QL-SA had good slow release performance and with the releasing time of 30 h in ethanol/water(1:1).The rate of cumulative release was 88.97% and the residual rate of AVM was 37.75%.Under UV irradiation for 8 h, the residual rate was 6.24%.It was confirmed that AVM-QL-SA had the function of resistance against UV.

Key words: lignin quaternary ammonium salt, polymers, avermectin, slow-release

中图分类号:

TQ35

卢晶, 罗华超, 张琼, 方桂珍, 任世学. 木质素季铵盐-海藻酸钠聚合物负载阿维菌素粉体的制备及抗紫外光性能分析[J]. 生物质化学工程, 2015, 49(3): 17-22.

LU Jing, LUO Hua-chao, ZHANG Qiong, FANG Gui-zhen, REN Shi-xue. Preparation and UV-shielding Properties of Quaternary Ammonium Salt of Lignin-sodium Alginate Polymer Loading Avermectin[J]. bce, 2015, 49(3): 17-22.

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木质素季铵盐-海藻酸钠聚合物负载阿维菌素粉体的制备及抗紫外光性能分析

Preparation and UV-shielding Properties of Quaternary Ammonium Salt of Lignin-sodium Alginate Polymer Loading Avermectin

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