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生物质化学工程

生物质化学工程 ›› 2009, Vol. 43 ›› Issue (2): 37-42.

• 论文 • 上一篇    下一篇

植物聚戊烯醇的理化特性和药理活性研究进展

王成章, 叶建中, 陈西娟, 陈虹霞, 杨兰   

  1. 中国林业科学研究院林产化学工业研究所;生物质化学利用国家工程实验室;国家林业局, 林产化学工程重点开放性实验室, 江苏, 南京, 210042
  • 收稿日期:2008-08-07 修回日期:1900-01-01 出版日期:2009-03-30 发布日期:2009-03-30

Research Progress of Physicochemical Properties and Pharmacological Activities of Plant Polyprenols

WANG Cheng-zhang, YE Jian-zhong, CHEN Xi-juan, CHEN Hong-xia, YANG Lan   

  1. Institute of Chemical Industry of Forest Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. on Forest Chemical Engineering, SFA, Nanjing 210042, China
  • Received:2008-08-07 Revised:1900-01-01 Online:2009-03-30 Published:2009-03-30

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摘要： 植物聚戊烯醇是一类异戊烯基结构聚合体的类脂化合物,与人体内多萜醇具有相似的结构特征和生理活性,而多萜醇是糖基与蛋白质生物合成的关键载体.本文重点介绍植物聚戊烯醇的结构类型、HPLC分析、结构鉴定方法和光谱特征、药理和临床应用.针对我国银杏叶加工存在的问题,提出要重点研究银杏叶聚戊烯醇新的有效活性成分,促进银各叶聚戊烯醇作为保健品和药物的开发.

关键词: 植物聚戊烯醇, 理化特性, 药理活性, 药物开发

Abstract: Plant polyprenols, which have similar structure and biological activity to dolichols in human body, are lipids of polymer with isoprenyl units. However, dolichols are key carriers in biosynthesis process of glycosyl derivatives with protein. The structure types, HPLC analysis, structural identification, spectral characteristics, pharmacology and clinical application of plant polyprenols were mainly introduced in this paper. According to present problems in processing of Ginkgo biloba L. leaves in China, it is suggested to mainly study the new bioactive components of polyprenols in G. biloba L. and promote the development of plant polyprenols from G. biloba L. as health care products and drug.

Key words: plant polyprenols, physicochemical properties, pharmacological activities, drug development

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