植物单宁构筑的水凝胶材料及其生物医药应用

doi:10.3969/j.issn.1673-5854.2023.04.001

Abstract

Abstract:

Plant tannins were very rich in nature, and a large number of phenolic hydroxyl groups contained in their molecular structure were easy to be chemically modified. At the same time, tannins had strong antioxidant, antiviral, antitumor and other biological activities, and had a significant inhibitory effect on bacteria and enzymes. In order to study the application of plant tannins in the field of biomedical materials, this article reviewed the research progress of tannin-based hydrogels and their potential applications in the fields of tissue engineering, drug delivery, and wound dressing, and the industrial preparation methods of materials were also summarized. Firstly, the design strategies and formation mechanisms of different types of tannin-based hydrogels were introduced in detail. In particular, the role of molecular structure and biochemical properties of tannins in the construction process of hydrogels were analyzed deeply. The specific application of hydrogels and the latest research hotspots were then elaborated. Finally, the current limitations of these materials were discussed, and the prospects of large-scale industrial production in the future were highlighted.

Key words: plant tannin, hydrogel material, tissue engineering, drug delivery, wound dressing

CLC Number:

TQ35

Xinyu HU. Plant Tannin-based Hydrogel Materials and Their Biomedical Applications[J]. Biomass Chemical Engineering, 2023, 57(4): 1-16.

Figures/Tables 7

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Table 1

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References 69

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凝胶材料 hydrogel material	核心优势 core advantages	应用方向 application direction	参考文献 reference
胶原蛋白/单宁 collagen/tannin	成胶快速，机械性能高 fast gelation and high mechanical properties	组织再生 tissue regeneration	[47]
海藻酸钠/单宁 sodium alginate/tannin	稳定性高，细胞黏附率高 high stability and high cell adhesion rate	植入模块 implant scaffold	[48]
DNA/单宁 DNA/tannin	原子经济性，组装快速 atomic economy, fast assembly	组织密封胶 tissue sealant	[49]
单宁/聚N, N-二甲基丙烯酰胺 tannin/poly(N, N-dimethylacrylamide)	机械性能高，细胞黏附率高 high mechanical properties and cell adhesion rate	组织模块 tissue scaffold	[13]
单宁/聚乙烯吡咯烷酮/三价铁 tannin/poly(vinyl pyrrolidone)/Fe³⁺	双重响应性，压缩模量高 dual stimuli-responsive property and highe compressive modulus	植入模块 implant scaffold	[50]
几丁质纳米纤维/没食子酸(水解单宁) chitin nanofibers/gallic acid(hydrolyzed tannin)	交联快速，黏附强度高 fast crosslinking and high adhesion strength	皮肤组织 skin tissue	[51]

凝胶材料 hydrogel material	核心优势 core advantages	应用方向 application direction	参考文献 reference
单宁/明胶 tannin/gelatin	吸水率高，pH可控性 high water absorption and pH controllability	营养物释放 nutrient release	[55]
单宁/明胶/单宁阿拉伯树胶 tannin/gelatin/tannin acacia senegal	负载率高，释放迅速 high load rate and fast release	体液释放 body fluid release	[56]
单宁/聚甲基丙烯酸 tannin/poly(methacrylic acid)	抗氧化性，交联度高 oxidation resistance and high degree of crosslinking	控制释放 control release	[57]
单宁/壳聚糖/磁性纳米粒子 tannin/chitosan/magnetic nanoparticles	pH敏感性，磁靶向性 pH-sensitive and magnetic targeting properties	远程缓释 remote sustained release	[58]
壳聚糖/海藻酸钠/单宁 chitosan/sodium alginate/tannin	稳定性高，负载率高 high stability and load efficiency	释放动力学 release kinetics	[59]
聚单宁酸 poly(tannic acid)	组装快速，抑菌性强 quick assembly and strong bacteriostasis	控制释放 control release	[60]
单宁/聚乙烯吡咯烷酮 tannin/poly(vinyl pyrrolidone)	pH敏感性，负载率高 pH-sensitive property and high load efficiency	控制释放 control release	[61]

凝胶材料 hydrogel material	核心优势 core advantages	应用方向 application direction	参考文献 reference
单宁/壳聚糖/普鲁兰多糖 tannin/chitosan/pullulan	吸水迅速，细胞相容性高 rapid water absorption and high cytocompatibility	伤口修复 wound healing	[62]
单宁/丝素蛋白 tannin/silk protein	抗氧化性强，抑菌性高 strong oxidation resistance and high bacteriostasis	皮肤修复 skin healing	[63]
羧化琼脂糖/单宁 carboxylated agarose/tannin	抗炎性强，生物相容性高 strong anti-inflammatory and high biocompatiblity	伤口消炎 wound anti-inflammatory	[64]
纤维素/单宁 cellulose/tannin	抑菌性强，释放率高 strong bacteriostatic and high release rate	伤口修复 wound repair	[65]
羟丙基甲壳素/单宁/铁 hydroxypropyl chitin/tannin/Fe	二元敏感性，抗菌范围广 dual stimuli-responsive property and wide range of antibacterial	感染治愈 infection cure	[12]
单宁/聚乙烯吡咯烷酮 tannin/poly(vinyl pyrrolidone)	抑菌性强，伤口修复快速 strong bacteriostatic and fast wound repair	临床创伤修复 clinical trauma repair	[66]

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Plant Tannin-based Hydrogel Materials and Their Biomedical Applications

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