乙酰丙酸还原胺化制备5-甲基-2-吡咯烷酮

Abstract

Abstract: The reductive amination of levulinic acid with ammonium formate as hydrogen and nitrogen donor to synthesize 5-methyl-2-pyrrolidone(5-MeP) in DMF solvent was developed and the mechanism of this process was proposed. The effects of various reaction conditions including temperature,reaction time,mass fraction and molar ratio of levulinic acid with ammonium formate and pH value on 5-methyl-2-pyrrolidone yield were investigated. Meanwhile,different solvents and levulinate derivatives were investigated in this system. The results showed that the properly increasing temperature,reaction time,the molar ratio and total mass fraction of levulinic acid and ammonium formate,and the pH value of system could improve the yield of 5-methyl-2-pyrrolidone. The polar aprotic solvents including formamide,DMA,DMSO and levulinate derivatives,such as methyl levulinate and α-angelica lactone,could also be respectively used as solvents and substrates in this system,too.

Key words: pyrrolidone, reductive amination, levulinic acid, biomass

CLC Number:

TQ31
TQ35

WANG Yanjun, LI Zheng, JIANG Yetao, CHEN Wei, ZENG Xianhai, SUN Yong, LIN Lu. Reductive Amination of Levulinic Acid to 5-Methyl-2-pyrrolidone[J]. bce, 2017, 51(2): 19-25.

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Reductive Amination of Levulinic Acid to 5-Methyl-2-pyrrolidone

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