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bce ›› 2017, Vol. 51 ›› Issue (1): 8-12.doi: 10.3969/j.issn.1673-5854.2017.01.002

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Preparation of Ethyl Cellulose/Naproxen Composite Microspheres Through Emulsion-solvent Evaporation Method

SUN Peipei1,2, CHEN Jinwei2, SHANG Shibin1,2, WANG Dan1,2, ZHANG Kaitao2   

  1. 1. Research Institute of Forestry New Technology, CAF, Beijing 100091, China;
    2. Institute of Chemical Industry of Forest Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. of Forest Chemical Engineering, SFA;Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China
  • Received:2016-04-13 Online:2017-01-30 Published:2017-01-23

Abstract: Ethyl cellulose/naproxen composite microspheres with high encapsulation efficiency were prepared by O/W emulsion-solvent evaporation method with ethyl cellulose as the carrier material and naproxen as the entrapped object. Orthogonal experiment was used to optimize the preparation process. And the results indicated that the optimal conditions were the mass ratio of ethyl cellulose and naproxen 3:1, ethyl cellulose addition 2.5%, polyvinyl alcohol addition 0.8%, Tween-80 addition 0.4%. Under these conditions, the encapsulation efficiency of naproxen was 88.97%. The morphology and structure of composite microspheres were investigated by scanning electron microscope(SEM), laser granularity analyzer and Fourier transform infrared spectroscopy(FT-IR). The SEM observation showed that composite microspheres were smooth, and laser granularity analyzer demonstrated that the mean diameter of particles was 14.014μm. The FT-IR showed that the characteristic adsorption peaks of EC and naproxen all appeared in the spectrum of microsphere and there was no new peak. This indicated no new compound generated during EC coating naproxen. The experiment of drug releasing indicated that the accumulative release rate increased with the increase of pH value of dissolution medium and reached the maximum of 82.5% at pH 9. And the composite microspheres showed better sustained release of drug.

Key words: ethyl cellulose, naproxen, composite microspheres, encapsulation efficiency, sustained release

CLC Number: