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›› 2011, Vol. 45 ›› Issue (2): 45-50.

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The State Art of View of Influenciable Main Factors in Acetone-Butanol Fermentation and Proposed Solutions

GAO Kai, LI Yun, YANG Xiu-shan   

  1. College of Life Sciences, Capital Normal University, 100048, Beijing
  • Received:2011-01-27 Revised:1900-01-01 Online:2011-03-30 Published:2011-03-30

Abstract: Major problems, which influenced on the revival of acetone-butanol fermentation (ABF),were analysized. And sporulation of solventogenic clostridia, low butanol yield, production of byproduct, and high substrate cost as well as the toxity of butanol etc. were considered. Reducing substrate cost by employing lignocelluloses as carbon resource has attracted extensive attention and efforts. In this review, these problems mentioned above were discussed. The molecular mechanism leading to the initiation of sporulation and solventogenesis is also investigated. Different strategies are employed in the metabolic engineering of clostridia that aim to enhancing solvent production, improve selectivity for butanol production, and increase the tolerance of clostridia to solvents. Here, the strategies to further improve strain performance and reduce the cost of biobutanol were proposed.

Key words: acetone-butanol fermentation, Metabolic engineering, Gas stripping, lignocellulose

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