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›› 2006, Vol. 40 ›› Issue (2): 23-24.

• 研究报道 • Previous Articles     Next Articles

An Improved Method for the Synthesis of 6-Nitrocoumarin

QI Gang1, TU Shu-zi2   

  1. 1. Department of Technology, Yancheng Institute of Technology, Yancheng 224003, China;2. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
  • Received:2005-12-20 Revised:1900-01-01 Online:2006-03-30 Published:2006-03-30

Abstract: 6-Nitrocoumarin was synthesized from coumarin through a treatment with NaNO3 and H2SO4. This method is benefit to control the quantity of nitrating agent and reduce the quantity of water. The reaction occurred under low temperature for the quantity of water was reduced, so the double bond is not oxidized. This method is convenient and effective.

Key words: coumarin derivative, 6-nitrocoumarin, nitrating reaction

CLC Number: