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Biomass Chemical Engineering ›› 2021, Vol. 55 ›› Issue (2): 45-49.doi: 10.3969/j.issn.1673-5854.2021.02.007

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Synthesis and Antifungal Activity of Hydronopyl Gemini Quaternary Ammonium Salts

Xuezhen FENG1, Zhuanquan XIAO2, Guorong FAN1, Zongde WANG1,*()   

  1. 1. College of Forestry, Jiangxi Agricultural University, East China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland Administration, Nanchang 330045, China
    2. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330027, China
  • Received:2020-03-09 Online:2021-03-30 Published:2021-03-23
  • Contact: Zongde WANG E-mail:zongdewang@163.com


Three novel hydronopylgemini quaternary ammonium salts, namely tetramethylene-1,4-bis-(hydronopyl dimethyl ammonium chloride)(2a), pentamethylene-1,5-bis-(hydronopyl dimethyl ammonium chloride)(2b) and hexamethylene-1,6-bis-(hydronopyl dimethyl ammonium chloride)(2c) were synthesized from hydronopyl dimethyl amine and three α, ω-dibromoalkanes, respectively. Their structures were characterized by NMR and MS. The inhibition activities of the target compounds against nine plant pathogens were evaluated by mycelium growth rate method. The results showed that the three compounds had excellent antifungal activity against the tested plant pathogens, and compound 2c had the best inhibitory effect, in which its inhibitory rates on Colletotrichum acutatu, Sphaeropsis sapinea, Fusicoccum aesuli, Phytophthora parasitica var.Nicotianae and Fusarium oxysporum were much higher than that of chlorothalonil at all concentrations(12.5-200 mg/L) tested.

Key words: hydronopyl, gemini quaternary ammonium salt, synthesis, antifungal activity

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