氢化诺卜基双子季铵盐的合成及抑菌活性

doi:10.3969/j.issn.1673-5854.2021.02.007

Abstract

Abstract:

Three novel hydronopylgemini quaternary ammonium salts, namely tetramethylene-1,4-bis-(hydronopyl dimethyl ammonium chloride)(2a), pentamethylene-1,5-bis-(hydronopyl dimethyl ammonium chloride)(2b) and hexamethylene-1,6-bis-(hydronopyl dimethyl ammonium chloride)(2c) were synthesized from hydronopyl dimethyl amine and three α, ω-dibromoalkanes, respectively. Their structures were characterized by NMR and MS. The inhibition activities of the target compounds against nine plant pathogens were evaluated by mycelium growth rate method. The results showed that the three compounds had excellent antifungal activity against the tested plant pathogens, and compound 2c had the best inhibitory effect, in which its inhibitory rates on Colletotrichum acutatu, Sphaeropsis sapinea, Fusicoccum aesuli, Phytophthora parasitica var.Nicotianae and Fusarium oxysporum were much higher than that of chlorothalonil at all concentrations(12.5-200 mg/L) tested.

Key words: hydronopyl, gemini quaternary ammonium salt, synthesis, antifungal activity

CLC Number:

TQ35
O621

Xuezhen FENG, Zhuanquan XIAO, Guorong FAN, Zongde WANG. Synthesis and Antifungal Activity of Hydronopyl Gemini Quaternary Ammonium Salts[J]. Biomass Chemical Engineering, 2021, 55(2): 45-49.

Figures/Tables 2

References 16

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化合物 compounds	质量浓度/(mg·L^-1) mass concentration	A	B	C	D	E	F	G	H	I
2a	200	100	67.6	69.8	100	100	81.8	100	100	100
	100	97.8	56.4	61.3	100	94.8	61.3	100	100	96.7
	50	91.2	43.6	43.2	100	79.4	45.4	100	100	87.6
	25	76.7	26.8	28.5	97.2	64.7	26.6	97.1	100	73.6
	12.5	31.2	13.4	13.3	58.2	29.5	16.2	74.8	100	27.8
2b	200	100	72.7	66.7	100	100	74.0	100	100	100
	100	92.2	60.4	51.8	100	100	60.8	100	100	97.4
	50	80.7	52.8	37.4	100	98.7	47.5	94.5	100	92.9
	25	52.6	27.0	23.6	100	96.3	36.2	93.9	100	87.5
	12.5	44.3	14.9	10.0	88.6	85.1	22.4	92.6	100	79.6
2c	200	100	83.0	78.0	100	100	94.8	100	100	100
	100	93.3	71.3	65.2	100	100	77.2	100	100	100
	50	87.9	55.7	50.7	100	98.9	60.4	100	100	93.6
	25	79.0	47.8	44.1	100	98.2	49.2	100	100	88.7
	12.5	70.8	26.2	29.3	89.6	93.6	29.7	100	100	82.3
百菌清 chlorothalonil	200	91.4	59.8	23.9	78.2	61.9	56.9	87.9	100	45.1
	100	80.2	57.9	18.7	65.8	61.6	49.8	84.5	100	41.5
	50	76.5	56.2	17.8	60.2	57.6	44.9	78.2	100	36.7
	25	75.9	54.0	17.8	58.3	57.1	24.4	76.6	100	36.4
	12.5	64.9	45.2	17.2	57.5	55.9	15.7	58.2	100	34.9

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Synthesis and Antifungal Activity of Hydronopyl Gemini Quaternary Ammonium Salts

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