3-对烯-1-胺及其席夫碱衍生物的抑菌活性研究

doi:10.3969/j.issn.1673-5854.2019.04.007

Biomass Chemical Engineering ›› 2019, Vol. 53 ›› Issue (4): 45-49.doi: 10.3969/j.issn.1673-5854.2019.04.007

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Antimicrobial Activities of p-Menth-3-en-1-amine and Its Schiff Base Derivatives

Shouji ZHU^1,^2,³(),Xiaoshu WANG³,Shichao XU¹,Zhendong ZHAO^1,*()

1. Institute of Chemical Industry of Forest Products, CAF; National Engineering Lab. for Biomass Chemical Utilization; Key Lab. of Chemical Engineering of Forest Products, National Forestry and Grassland Administration; Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China
2. College of Chemical and Environmental Engineering, Hanshan Normal University, Chaozhou 521041, China
3. College of Food and Biochemical Engineering, Guangxi Science & Technology Normal University; Guangxi Universities Key Laboratory of Sugar Engineering Integrated Technology, Laibin 546199, China

Received:2017-09-29 Online:2019-07-30 Published:2019-08-05
Contact: Zhendong ZHAO E-mail:zsj82633829@126.com;zdzhao@189.cn
Supported by:
“十二五”国家科技支撑计划资助(2015BAD15B04)

Abstract

Abstract:

The antimicrobial activities of p-menth-3-en-1-amine(1) and its Schiff base derivatives(2a-2l) against Staphylococcus aureus(gram-positive bacteria), Klebsiella pneumonia(gram-negative bacterium) and Candida albicans (fungus) were measured by using the microbroth dilution method. Then, the structure-activity relationship was established. The results showed that some products had certain antibacterial activities against these pathogenic bacteria. Compound 1 had the strongest antimicrobial activity against Staphylococcus aureus and the minimal inhibitory concentration(MIC) was 56.25 mg/L. Compound 2h and 2i had the strongest antimicrobial activity against Klebsiella pneumonia and the MICs were 112.5 mg/L. Compounds 2l had the strongest antimicrobial activities against Candida albicans and the MIC was 28.125 mg/L. The structure-activity relationship indicated that the antimicrobial activity would be stronger when the chlorine or bromine atom was introduced into the Schiff base derivatives; the antimicrobial activities of Schiff base derivatives containing a pyridine ring were higher than those of the Schiff base derivatives containing a furan, pyrrole or thiophene.

Key words: p-menth-3-en-1-amine, Schiff base derivatives, antimicrobial activity

CLC Number:

TQ35

Shouji ZHU,Xiaoshu WANG,Shichao XU,Zhendong ZHAO. Antimicrobial Activities of p-Menth-3-en-1-amine and Its Schiff Base Derivatives[J]. Biomass Chemical Engineering, 2019, 53(4): 45-49.

Figures/Tables 1

References 12

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化合物 compounds	结构式 structure	最小抑菌浓度minimal inhibitory concentration(MIC)/(mg·L^-1)
化合物 compounds	结构式 structure	金黄色葡萄球菌 Staphylococcus aureus	肺炎克雷伯氏菌 Klebsiella pneumoniae	白色念珠菌 Candida albicans
1		56.25	450	112.5
2a		>450	>450	450
2b		450	225	112.5
2c		450	450	112.5
2d		450	225	56.25
2e		450	225	225
2f		>450	450	225
2g		450	225	56.25
2h		450	112.5	56.25
2i		>450	112.5	112.5
2j		>450	>450	450
2k		>450	450	225
2l		225	225	28.125
硫酸卡那霉素 Kanamycin sulfate	—	0.44	0.44	112.5
利福平 Rifampicin	—	3.52	0.44	450

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Antimicrobial Activities of p-Menth-3-en-1-amine and Its Schiff Base Derivatives

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