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Biomass Chemical Engineering ›› 2019, Vol. 53 ›› Issue (1): 25-32.doi: 10.3969/j.issn.1673-5854.2019.01.004

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Response Surface Optimization of Hydroxypropyl Chitosan Synthesis

Rui GUO(),Yao ZHANG*(),Shuang HAN,Ning WANG   

  1. Key Laboratory of Auxiliary Chemistry & Technology for Chemical Engineering, Ministry of Education, Shaanxi University of Science and Technology, Xi'an 710021, China
  • Received:2018-01-25 Online:2019-01-30 Published:2019-03-15
  • Contact: Yao ZHANG E-mail:365726475@qq.com;543100811@qq.com
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Hydroxypropyl chitosan(HPCS) was synthesized from chitosan(CTS) and propylene oxide. The structure and morphology of HPCS were characterized by infrared spectroscopy(FT-IR), 1H nuclear magnetic resonance(1H NMR), X-ray diffraction(XRD) and environmental scanning electron microscopy(ESEM). And the effects of the synthesis process on the intrinsic viscosity were investigated. The results showed that the hydroxypropyl group was successfully grafted onto chitosan and HPCS was obtained. On the basis of single factor experiment, the response surface methodology was used to optimize the process. The optimum conditions for HPCS synthesis were reaction temperature 60 ℃, reaction time 6 h, NaOH mass fraction 30%, alkalization time 20 min and the amount of propylene oxide 12.6 g. Under these conditions, the intrinsic viscosity of HPCS was 206.32 mL/g, the relative molecular mass was 2.738×105, and the degree of substitution(DS)was 0.426.

Key words: hydroxypropyl chitosan, response surface optimization, intrinsic viscosity

CLC Number: