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bce ›› 2018, Vol. 52 ›› Issue (1): 23-28.doi: 10.3969/j.issn.1673-5854.2018.01.004

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Quantitative Determination of 3,4,5-Trimethoxybenzoic Acid

XU Man, WANG Yongmei, ZHANG Liangliang, HU Xinyu   

  1. Institute of Chemical Industry of Forest Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. of Forest Chemical Engineering, SFA;Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China
  • Received:2016-11-28 Online:2018-01-30 Published:2018-02-06

Abstract: High performance liquid chromatography and titration method were studied for quantitative determination of 3,4,5-trimethoxybenzoic acid. The testing conditions of the methods were proposed, and the measured results were analysed to estimate and evaluate the accuracy and practical applicability of two methods. The Grubbs test results showed that there was no outlier in the two groups of measuring data determined by HPLC and titration method. The data of two methods were both in compliance with normal distribution by testing the skewness and kurtosis coefficient. The t-test of both measurements was simultaneously performed, which indicated that there was no significant difference between the determination value of two methods. The results also showed HPLC method had higher accuracy and precision compared with the titration method, so the HPLC method could be the first choice and then the titration method.

Key words: 3,4,5-trimethoxybenzoic acid, high performance liquid chromatography, titration method, quantitative determination, statistic analysis

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