乳化-溶剂挥发法制备乙基纤维素/萘普生复合微球

doi:10.3969/j.issn.1673-5854.2017.01.002

bce ›› 2017, Vol. 51 ›› Issue (1): 8-12.doi: 10.3969/j.issn.1673-5854.2017.01.002

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Preparation of Ethyl Cellulose/Naproxen Composite Microspheres Through Emulsion-solvent Evaporation Method

SUN Peipei^1,2, CHEN Jinwei², SHANG Shibin^1,2, WANG Dan^1,2, ZHANG Kaitao²

1. Research Institute of Forestry New Technology, CAF, Beijing 100091, China;
2. Institute of Chemical Industry of Forest Products, CAF;National Engineering Lab. for Biomass Chemical Utilization;Key and Open Lab. of Forest Chemical Engineering, SFA;Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China

Received:2016-04-13 Online:2017-01-30 Published:2017-01-23

Abstract

Abstract: Ethyl cellulose/naproxen composite microspheres with high encapsulation efficiency were prepared by O/W emulsion-solvent evaporation method with ethyl cellulose as the carrier material and naproxen as the entrapped object. Orthogonal experiment was used to optimize the preparation process. And the results indicated that the optimal conditions were the mass ratio of ethyl cellulose and naproxen 3:1, ethyl cellulose addition 2.5%, polyvinyl alcohol addition 0.8%, Tween-80 addition 0.4%. Under these conditions, the encapsulation efficiency of naproxen was 88.97%. The morphology and structure of composite microspheres were investigated by scanning electron microscope(SEM), laser granularity analyzer and Fourier transform infrared spectroscopy(FT-IR). The SEM observation showed that composite microspheres were smooth, and laser granularity analyzer demonstrated that the mean diameter of particles was 14.014μm. The FT-IR showed that the characteristic adsorption peaks of EC and naproxen all appeared in the spectrum of microsphere and there was no new peak. This indicated no new compound generated during EC coating naproxen. The experiment of drug releasing indicated that the accumulative release rate increased with the increase of pH value of dissolution medium and reached the maximum of 82.5% at pH 9. And the composite microspheres showed better sustained release of drug.

Key words: ethyl cellulose, naproxen, composite microspheres, encapsulation efficiency, sustained release

CLC Number:

TQ352.79

SUN Peipei, CHEN Jinwei, SHANG Shibin, WANG Dan, ZHANG Kaitao. Preparation of Ethyl Cellulose/Naproxen Composite Microspheres Through Emulsion-solvent Evaporation Method[J]. bce, 2017, 51(1): 8-12.

References

[1] 郭波红,程怡. 乙基纤维素在缓控释药制剂中的应用研究[J]. 中医药学刊,2002,20(5):601-603.
[2] 王秀丽,党晓芳,廖艳,等. 乙基纤维素骨架缓释片处方工艺对水溶性药物释放的影响因素研究[J]. 药学实践杂志,2014,32(2):116-117.
[3] INDIRAN P S,IRINA R,JAMES A S,et al. Sustained release theophylline tablets by direct compression:Part 1:Formulation and in vitro testing[J]. International Journal Pharmaceutics,1998,164(1/2):1-10.
[4] SIEPMANN J,SIEPMANN F. Stability of aqueous polymeric controlled release film coatings[J]. International Journal Pharmaceutics,2013,457(2):437-445.
[5] SHI P J,ZUO Y,ZOU Q,et al. Improved properties of incorporated chitosan film with ethyl cellulose microspheres for controlled release[J]. International Journal Pharmaceutics,2009,375(1/2):67-74.
[6] 金刚,王洁,王涛,等. 阿司匹林缓释固体分散体的制备及体外溶出度的研究[J]. 吉林化工学院学报,2014,31(3):35-37.
[7] SENGEL C T,HASCICEK C,GONUL N. Development and in-vitro evaluation of modified release tablets including ethylcellulose microspheres loaded with diltiazem hydrochloride[J]. Journal of Microencapsulation,2006,23(2):135-152.
[8] DAS M K,RAO K R. Evaluation of zidovudine encapsulated ethylcellulose microspheres prepared by water-in-oil-in-oil(w/o/o) double emulsion solvent diffusion technique[J]. Acta Poloniae Pharmaceutica,2006,63(2):141-148.
[9] SHARA J,SINGLA A K,DHAWAN S. Zinc-naproxen complex:Synthesis,physicochemical and biological evaluation[J]. International Journal of Pharmaceutics,2003,260(2):217-227.
[10] BROGDEN R N,HEEL R C,SPEIGHT T M. Naproxen up to date:A review of its pharmacological properties and therapeutic efficacy and use in rheumatic disease and pain states[J]. Drugs,1979,18(4):241-277.
[11] OKADA H,TOGUCHI H. Biodegradable microspheres in drug delivery[J]. Critical Reviews in Therapeutic Drug Carrier Systems,1995,12(1):1-99.
[12] 陈莉敏,李柱来,王津. 萘普生缓释微球制备工艺及性能研究[J]. 天然产物研究与开发,2007,19(5):878-880,889.
[13] 张敏,张丽叶. 洛伐他汀聚乳酸缓释微球的制备及其体外释药[J]. 北京化工大学学报:自然科学版,2011,38(2):94-98.
[14] WANG F J,WANG C H. Sustained release of etanidazole from spray dried microspheres prepared by non-halogenated solvents[J]. Journal of Controlled Release,2002,81(3):263-280.
[15] GAVINI E,CHETONI P,COSSU M,et al. PLGA microspheres for the ocular delivery of a peptide drug,vancomycin using emulsification/spray-drying as the preparation method:In vitro/in vivo studies[J].European Journal of Pharmaceutics and Biopharmaceutics,2004,57(2):207-212.
[16] 张严之,李奎锋,黄婷,等. 超临界流体技术制备5-氟尿嘧啶-吲哚美辛-聚乳酸缓释微球[J]. 复合材料学报,2011,28(1):21-25.
[17] 曾烨婧,王连艳,马光辉,等. 快速膜乳化法制备紫杉醇聚乳酸类微球[J]. 过程工程学报,2010,10(3):568-575.
[18] 冯敏,吴伟荣,潘仕荣,等. 萘普生核壳型共聚物纳米胶束的制备及特性[J]. 中国药学杂志,2002,37(7):509-512.

Preparation of Ethyl Cellulose/Naproxen Composite Microspheres Through Emulsion-solvent Evaporation Method

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