基于纤维素模板的聚合物空心微球作为药物载体的性能研究及分析

doi:10.3969/j.issn.1673-5854.2015.03.001

Abstract

Abstract: Hydroxypropylcellulose (HPC), a natural polymer, was chosen as a biocompatible and biodegradable template to prepare two kinds of polymeric hollow microspheres, i.e., poly(N-isopropylacrylamide)-co-poly(acrylic acid) (PNIPAm-co-PAA) microgels and poly(N-isopropylacrylamide)-poly(acrylic acid) (PNIPAm-PAA) hydrogel capsules by using different polymerization methods.The drug loading capacity and releasing behaviors of PNIPAm-co-PAA microgels and PNIPAm-PAA hydrogel capsules as drug carriers were investigated by using anticancer drug, Doxorubicin hydrochloride (Dox), as hydrophilic model drug.The results indicated that Dox could be encapsulated in PNIPAm-co-PAA microgels and PNIPAm-PAA hydrogel capsules with high drug loading driven by the electrostatic interaction.The characteristic sustained-releases of Dox from these two kinds of microspheres were observed under physiological pH and temperature.More encouragingly, the release of Dox exhibited a dual-responsivity to temperature and pH.In vitro cytotoxicity assay indicated that Dox-loaded PNIPAm-co-PAA microgels and PNIPAm-PAA hydrogel capsules had high antitumor activity, and implied that they might be a potential drug delivery carrier especially for water-soluble or polypeptide drugs, as well as applying in the wood adhesive preservation, etc.

Key words: polymeric hollow microspheres, poly (N-isopropylacrylamide), poly (acrylic acid), drug carrier

CLC Number:

TQ35

NAN Jing-ya, LIU Yu-peng, CHEN Ying, WANG Chun-peng, CHU Fu-xiang. Properties of Cellulose-based Polymeric Hollow Microspheres as Drug Carriers[J]. bce, 2015, 49(3): 1-6.

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Properties of Cellulose-based Polymeric Hollow Microspheres as Drug Carriers

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