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›› 2013, Vol. 47 ›› Issue (2): 1-5.doi: 10.3969/j.issn.1673-5854.2013.02.001

• 研究报告 •     Next Articles

Preparation of Alginate/Chitosan Composite Microspheres and Their Application in Controlled Release

QIAN Ru-dan, RUAN Ling, LI Jie, WANG Han-yu, LI Jian-fa   

  1. Department of Chemistry, Shaoxing University, Shaoxing 312000, China
  • Received:2012-10-25 Revised:1900-01-01 Online:2013-03-30 Published:2013-03-30

Abstract: The active ingredient was encapsulated in the alginate microgel using spray-drying technology. The microgel was crosslinked with calcium cations and chitosan to prepare the composite microspheres. Their application in controlled release was investigated using vitamin B2 as the model drug. SEM analysis indicated that the aggregate structure was formed after compositely crosslinking of alginate microgel. In comparison with alginate microspheres crosslinked solely by calcium cations, the composite microspheres showed slower release of vitamin B2, with t50 prolonged by about 6 times. The longer the crosslinking time and higher dose of crosslinker, the slower the release of vitamin B2. The release time of vitamin B2 was extended to above 24 h at the loading amount of 16.0%-35.6%. The release process was dominated by Fickian diffusion.

Key words: alginate, chitosan, microgel, controlled release

CLC Number: