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生物质化学工程 ›› 2020, Vol. 54 ›› Issue (1): 60-66.doi: 10.3969/j.issn.1673-5854.2020.01.010

• 综述评论 • 上一篇    

以糠醛为原料的δ-戊内酯合成及应用研究进展

徐榕徽,王国胜*()   

  1. 沈阳化工大学 化学工程学院; 辽宁省高校化工技术重点实验室, 辽宁 沈阳110142
  • 收稿日期:2019-01-25 出版日期:2020-01-30 发布日期:2020-02-11
  • 通讯作者: 王国胜 E-mail:wgsh-lyc@163.com
  • 基金资助:
    辽宁省重点研发计划资助项目(2017230001)

Research Progress in Synthesis and Application of δ-Valerolactone Base on Furfural

Ronghui XU,Guosheng WANG*()   

  1. Liaoning Provincial Key Laboratory of Chemical Technology, College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang 110142, China
  • Received:2019-01-25 Online:2020-01-30 Published:2020-02-11
  • Contact: Guosheng WANG E-mail:wgsh-lyc@163.com
  • Supported by:
    辽宁省重点研发计划资助项目(2017230001)

摘要:

综述了以糠醛为原料,经环戊酮制δ-戊内酯,经糠醇及四氢糠醇制1,5-戊二醇再制δ-戊内酯,以及经四氢呋喃制δ-戊内酯的3种主要合成途径并简述了经其他糠醛衍生物合成δ-戊内酯的途径;同时对δ-戊内酯在合成医药中间体和聚酯两方面的应用进行了总结。由于δ-戊内酯结构广泛存在于具有生物活性和光学活性的化合物中,可应用于医药领域,δ-戊内酯自身易聚合,也可与其他化合物形成聚交酯,合成的共聚物具有良好的生物相容性和生物可降解性,这使其在可生物降解材料领域应用受到关注,因此以糠醛为原料制备δ-戊内酯生产技术是未来的研究热点。

关键词: 糠醛, 衍生物, δ-戊内酯, 合成

Abstract:

Study on three main synthetic routes of δ-valerolactone by cyclopentanone, 1, 5-pentanediol by furfuryl alcohol and tetrahydrofurfuryl and by tetrahydrofuran are reviewed using furfural as raw material. The synthesis of δ-valerolactone by other furfural derivatives is also described. The applications of δ-valerolactone in pharmaceutical intermediates and polyesters are summarized, which is used in pharmaceutical industry because its structure is widely found in bioactive and optically active compounds. It is easy to polymerize, and can also form polylactide with other compounds.The polymer has biocompatibility and biodegradability, which makes its application in the field of biodegradable materials attractive. Therefore the preparation of the δ-valerolactone production technology using furfural as raw material is a hot topic in the future.

Key words: furfural, derivatives, δ-valerolactone, synthesis

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