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生物质化学工程

生物质化学工程 ›› 2013, Vol. 47 ›› Issue (2): 1-5.doi: 10.3969/j.issn.1673-5854.2013.02.001

• 研究报告 •    下一篇

海藻酸盐/壳聚糖复合微球的制备及其控制释放作用

钱汝丹, 阮玲, 李洁, 王寒玉, 李建法   

  1. 绍兴文理学院 化学系, 浙江 绍兴 312000
  • 收稿日期:2012-10-25 修回日期:1900-01-01 出版日期:2013-03-30 发布日期:2013-03-30
  • 通讯作者: 李建法,男,博士,教授;研究领域:功能材料与控制释放;E-mail:ljf@usx.edu.cn。

Preparation of Alginate/Chitosan Composite Microspheres and Their Application in Controlled Release

QIAN Ru-dan, RUAN Ling, LI Jie, WANG Han-yu, LI Jian-fa   

  1. Department of Chemistry, Shaoxing University, Shaoxing 312000, China
  • Received:2012-10-25 Revised:1900-01-01 Online:2013-03-30 Published:2013-03-30

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摘要： 采用喷雾干燥法将活性成分包载到海藻酸钠微凝胶中,再经钙离子和壳聚糖交联得到复合微球。以维生素B2为模型药物探讨了微球的控制释放效果和机理。扫描电镜分析表明海藻酸钠微凝胶经复合交联后形成了团聚体结构。与单一钙离子交联的海藻酸盐微球相比,复合微球对维生素B2释放更慢,半数释放时间(t50)延长约6倍,且交联时间越长、交联剂用量越高,维生素B2释放越慢。当载药量介于16.0%～35.6%时,维生素B2释放时间达24 h以上,释放过程主要受费克扩散控制。

关键词: 海藻酸盐, 壳聚糖, 微凝胶, 控制释放

Abstract: The active ingredient was encapsulated in the alginate microgel using spray-drying technology. The microgel was crosslinked with calcium cations and chitosan to prepare the composite microspheres. Their application in controlled release was investigated using vitamin B2 as the model drug. SEM analysis indicated that the aggregate structure was formed after compositely crosslinking of alginate microgel. In comparison with alginate microspheres crosslinked solely by calcium cations, the composite microspheres showed slower release of vitamin B2, with t50 prolonged by about 6 times. The longer the crosslinking time and higher dose of crosslinker, the slower the release of vitamin B2. The release time of vitamin B2 was extended to above 24 h at the loading amount of 16.0%-35.6%. The release process was dominated by Fickian diffusion.

Key words: alginate, chitosan, microgel, controlled release

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